Additive effects of insulin and muscle contraction on fatty acid transport and fatty acid transporters, FAT/CD36, FABPpm, FATP1, 4 and 6
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چکیده
منابع مشابه
The Regulation of Fatty Acid Transport and Transporters in Insulin-, and Contraction- Stimulated Skeletal Muscle
THE REGULATION OF FATTY ACID TRANSPORT AND TRANSPORTERS IN INSULIN-, AND CONTRACTION-STIMULATED SKELETAL MUSCLE Swati S. Jain Advisor: University of Guelph, 2011 Professor A. Bonen The clearance of circulating glucose and long-chain fatty acids (FA) into skeletal muscle involves the translocation of glucose transporter GLUT4, fatty acid translocase (FAT/CD36), plasma membrane associated fatty a...
متن کاملFatty acid transporters, transport and metabolism
James G. Nickerson, Hakam Alkhateeb, Carley R. Benton, James Lally, Jennifer Nickerson, Xiao-Xia Han, M. H. Wilson, Swati S. Jain, Laelie A. Snook, Jan. F.C. Glatz, Adrian Chabowski, Joost J.F.P. Luiken, and Arend Bonen From the 1 Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada, the Department of Laboratory Medical Sciences, Hashemite U...
متن کاملStimulatory effects of leptin and muscle contraction on fatty acid metabolism are not additive.
Leptin has been shown to acutely stimulate fatty acid oxidation and triacylglycerol hydrolysis in skeletal muscle. These effects are similar to those induced by muscle contraction alone. Several studies have demonstrated that, during aerobic exercise, plasma leptin concentrations are well maintained; however, none has examined whether the stimulatory effects of leptin and contraction on muscle ...
متن کاملOverexpression of membrane-associated fatty acid binding protein (FABPpm) in vivo increases fatty acid sarcolemmal transport and metabolism.
Fatty acid translocase (FAT/CD36) is a key fatty acid transporter in skeletal muscle. However, the effects on fatty acid transport by another putative fatty acid transporter, plasma membrane-associated fatty acid binding protein (FABPpm), have not been determined in mammalian tissue. We examined the functional effects of overexpressing FABPpm on the rates of 1) palmitate transport across the sa...
متن کاملInsulin stimulates fatty acid transport by regulating expression of FAT/CD36 but not FABPpm.
Because insulin has been shown to stimulate long-chain fatty acid (LCFA) esterification in skeletal muscle and cardiac myocytes, we investigated whether insulin increased the rate of LCFA transport by altering the expression and the subcellular distribution of the fatty acid transporters FAT/CD36 and FABPpm. In cardiac myocytes, insulin very rapidly increased the expression of FAT/CD36 protein ...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2009
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2009.06.020